Here is a post that discusses the Good Friday account when Jesus said “My God, why have you abandoned me?”
creedcodecult.com/understanding-jesus-cry-of-abandonment/
The article distinguishes between the Protestant understanding of the Cross (called Penal Substitution) and the Catholic understanding of the Cross, which aren’t the same.
Please discuss! This issue needs more attention! 
Thank you for sharing. I now have a much greater appreciation for Psalm 22.
Yes, as a devout Jew, Jesus would have been quite familiar with this Psalm, and also would have used it to illustrate for those present just exactly who He was…in case they still persisted in denying it.
I’ll simply relate Pope John Paul II’s comment
After the words in Gethsemane come the words uttered on Golgotha, words which bear witness to this depth unique in the history of the world–of the evil of the suffering experienced. When Christ says: “My God, my God, why have you abandoned me?”, His words are not only an expression of that abandonment which many times found expression in the Old Testament, especially in the psalms and in particular in that Psalm 22(21) from which come the words quoted.[47] One can say that these words on abandonment are born at the level of that inseparable union of the Son with the Father, and are born because the Father “laid on him the iniquity of us all.”[48] They also foreshadow the words of St. Paul: “For our sake he made him to be sin who knew no sin.”[49] Together with this horrible weight, encompassing the “entire” evil of the turning away from God which is contained in sin, Christ, through the divine depth of His filial union with the Father, perceives in a humanly inexpressible way this suffering which us the separation, the rejection by the Father, the estrangement from God. But precisely through this suffering He accomplishes the Redemption, and can say as He breathes His last: “It is finished.”
Salvifici Doloris
ewtn.com/faith/teachings/rdmpc1.htm
Psalm 22.
Not a biblical scholar- but I’ve always considered this as an indication of the truth that Jesus was both God and Man. Truly Man… He truly felt as we felt. In the midst of His persecution He cried in exasperation out of feeling, not intellect. He knew God had not abandoned Him, but as a man on a cross pierced with nails He could not help but feel that way. Certainly foreshadowed in the Psalm, and as the article kind of says, "… praying the prayer all men pray when times get rough: “God, where are you? Why wont you rescue me from my suffering?”
Christ knew the why, He knew He had to endure this as an act of love for all mankind, intellectually as man and certainly as God He knew-- but as a human He could not help but feel what most humans would feel and cry out that sentiment in prayer.
I take it to mean that Jesus suffered the effect of being separated from God’s presence - as one through whom every sin is being passed to be expunged - but that does not mean God has abandoned Him but that He is speaking with and for all of unreleased mankind as part of His mediation.
It’s from Psalm 22: 1. Notices, though how it ends: The afflicted shall eat and be satisfied.
Ps 22:1-26
1 My God, my God, why hast thou forsaken me?
Why art thou so far from helping me, from the words of my groaning?
2 O my God, I cry by day, but thou dost not answer;
and by night, but find no rest.
3 Yet thou art holy,
enthroned on the praises of Israel.
4 In thee our fathers trusted;
they trusted, and thou didst deliver them.
5 To thee they cried, and were saved;
in thee they trusted, and were not disappointed.
6 But I am a worm, and no man;
scorned by men, and despised by the people.
7 All who see me mock at me,
they make mouths at me, they wag their heads;
8 “He committed his cause to the Lord; let him deliver him,
let him rescue him, for he delights in him!”
9 Yet thou art he who took me from the womb;
thou didst keep me safe upon my mother’s breasts.
10 Upon thee was I cast from my birth,
and since my mother bore me thou hast been my God.
11 Be not far from me,
for trouble is near
and there is none to help.
12 Many bulls encompass me,
strong bulls of Bashan surround me;
13 they open wide their mouths at me,
like a ravening and roaring lion.
14 I am poured out like water,
and all my bones are out of joint;
my heart is like wax,
it is melted within my breast;
15 my strength is dried up like a potsherd,
and my tongue cleaves to my jaws;
thou dost lay me in the dust of death.
16 Yea, dogs are round about me;
a company of evildoers encircle me;
they have pierced**(“Psalm 22 RSVCE - Plea for Deliverance from Suffering and - Bible Gateway”)] my hands and feet—
17 I can count all my bones—
they stare and gloat over me;
18 they divide my garments among them,
and for my raiment they cast lots.
19 But thou, O Lord, be not far off!
O thou my help, hasten to my aid!
20 Deliver my soul from the sword,
my life from the power of the dog!
21 Save me from the mouth of the lion,
my afflicted soul from the horns of the wild oxen!
22 I will tell of thy name to my brethren;
in the midst of the congregation I will praise thee:
23 You who fear the Lord, praise him!
all you sons of Jacob, glorify him,
and stand in awe of him, all you sons of Israel!
24 For he has not despised or abhorred
the affliction of the afflicted;
and he has not hid his face from him,
but has heard, when he cried to him.
25 From thee comes my praise in the great congregation;
my vows I will pay before those who fear him.
26 The afflicted shall eat and be satisfied;
those who seek him shall praise the Lord!
May your hearts live for ever!
It’s clear to me from JPII’s remarks that he believed that the cry of Jesus on the Cross…“My God, My God, why have you abandoned Me?”…was in relation to Jesus bearing the sins of humanity and suffering the effects of these sins in feeling the abandonment of God. He called it a mystery related to the depth of the Hypostatic Union. He never lost His Communion with the Father but He experienced the separation that results from sin.
This refutes what Catholic Dude posted in CreedCodeCult.
God made him who had no sin to be sin for us, so that in him we might become the righteousness of God. 2 Corinthians 5:21