Wow, that’s quite a question!
Marital conflict can come from many, many different sources:
Stress
Physical issues (illness, sensory intregation issues)
Selfishness
Culture
Family Culture Clashes
Geographic issues
environmental issues (molds, allergies, etc.)
Childhood issues
Parental issues
My wife and I had a whole host of issues to work through soon after we were married and only about 1% of it was what I would classify as “spiritual”.
I would very strongly recommend against blaming marital problems on a spiritual source until after you saw a counselor for a good, long time. And reduced other stresses on the marriage.
For example: Do y’all work different shifts?
Is one person sensitive to sounds and the other not?
Is one person like a certain form of entertainment and the other not? (My wife hates football - I love it)
Are allergens an issue (allergic to dust/mold/pets/plants in the house)?
Once these questions are dealt with, then move to a spiritual side. On the other hand, blessing a house is easy and free - just get your priest to do it. Just don’t expect that you and your spouse to magically start getting along.