No, provided the required conditions according to law are all met. Mortal sin does not invalidate a marriage.
It does, however, impute the additional mortal sin of sacrilege on the party in mortal sin. The graces of the Sacrament are also ineffective until the guilt party confesses and is absolved.
Not invalid for that reason at least. Also, when one spouse is unbaptized the valid marriage does not bring an increase of sanctifying grace or sacramental grace.
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