I can’t speak for anyone else, but I definitely feel that my relationship with the gods and my ancestors is reciprocated. In my religion, we dislike the term “prayer” except in specific circumstances, as it carries connotations that aren’t necessarily valid for our understanding of what occurs, but they have never failed to give me guidance and assistance, even if it was what I needed rather than what I wanted.
I don’t know about the One True God thing, as I’m not a Christian. I tend to interpret that as just a more emphatic way of expressing that there are no other gods available to you as Christians and that your god claims to be the supreme god, not necessarily that there aren’t other gods of some sort.