In his own inexplicable fashion, God was able to use the mouth of a corrupt ruler to declare a divine truth. Caiaphas meant his utterance for evil, but Jehovah so ordered the words that they expressed a magnificent truth (cf. Gen. 50:20).
The statement heralded the doctrine of the atoning death of Jesus. It was said that “one man should die for (huper) the people….” The Greek preposition huper literally means “over.” Out of that concept grew the sense of protection or defense (Robertson, 630). Thus, Jesus was to die “on behalf of,” or “for the benefit of,” others. Without him, there is no salvation.
John also notes that the Lord’s death would result in redemption being offered universally, i.e., to the Jewish “nation,” and to “the [potential] children of God that are scattered abroad” (Gentiles).
Finally, all who submit to Christ (Heb. 5:8-9) are to be “gathered together into one” (i.e., body, church —Eph. 4:4; 1:22-23).