L
Lisa4Catholics
Guest
Schiavo Autopsy Will Not Confirm Diagnosis
http://www.medpagetoday.com/images/blue_dot.gif By Peggy Peck, Senior Editor, MedPage Today
Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of Pennsylvania School of Medicine.
March 31, 2005
Also covered by: CNN, New York Times, USA Today http://www.medpagetoday.com/images/blue_dot.gifMedPage Today Action Points
PINELLAS PARK, Fla,-Neurologists say the autopsy that is planned to be performed on Terri Schiavo will not definitively confirm a diagnosis of persistent vegetative state.
“Persistent vegetative state or minimally conscious state is a clinical diagnosis,” says Michael De Georgia, MD, head of the neurology/neurosurgery intensive care unit at the Cleveland Clinic Foundation. “It cannot be confirmed by autopsy.”
Patients in a persistent vegetative state are a subgroup who suffer severe anoxic brain injury and progress to a state of wakefulness without awareness.
Michael Schiavo, husband and guardian of Terri Schiavo, and Mary and Bob Schindler, Ms. Schiavo’s parents, engaged in a contentious public and legal dispute over the decision to remove Ms. Schiavo’s feeding tube, but both said they wanted an autopsy and both say the post-mortem exam will provide evidence to finally nail down Ms. Schiavo’s diagnosis.
Michael Schiavo said all along that his wife was in a persistent vegetative state and that she would not want to be maintained in that state. The Schindlers contended that their daughter was minimally conscious and would not agree to have her feeding tube removed.
The tube was removed by court order on March 18 and neither the intercession of Congress nor more than a score of court challenges succeeded in replacing the tube.
“The [pathologic examination of the] brain can’t tell if there is a persistent vegetative state or not,” says Harvard neuropathologist E. Tessa Hedley Whyte, MD. “The autopsy will show damage – probably mostly scarring now – and that damage will most likely correspond to some extent to what was seen on images.”
According to court records, CT scans performed in 1996 and 2002 revealed “diffuse encephalomalacia and infarction consistent with anoxia, hydrocephalus ex vacuo, neural stimulator present.”
Dr. De Georgia says that the extent of brain damage, confirmed on autopsy, “does reflect the absence of viable brain cells and the fewer brains cells a patient has the less likely it is that the patient will be conscious. But there is no standard cutoff that says if you lose this many brain cells you are in a persistent vegetative state.”
Michael Williams, MD, an associate professor at Johns Hopkins in Baltimore, puts it this way. “If you only had the brain to look at and you didn’t know anything about the history of the patient, pathology alone cannot prove or disprove a diagnosis of persistent vegetative state.” Dr. Williams says it is likely that autopsy will show “widespread damage to the cortex – a condition called laminar necrosis – and it is likely that there will also be significant damage to the thalamus.” While Dr. Williams says the autopsy can’t confirm the diagnosis of persistent vegetative state, he says that receiving an autopsy report sometimes helps a family that is struggling to accept the diagnosis. “Sometimes additional evidence from a CT scan or an autopsy report – something concrete – helps bring some final understanding or acceptance,” he said.
http://www.medpagetoday.com/images/blue_dot.gif By Peggy Peck, Senior Editor, MedPage Today
Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of Pennsylvania School of Medicine.
March 31, 2005
Also covered by: CNN, New York Times, USA Today http://www.medpagetoday.com/images/blue_dot.gifMedPage Today Action Points
- Patients following news stories about the Schiavo case may have questions about her planned autopsy. Review with these patients the clinical diagnostic criteria for persistent vegetative state and minimally conscious state.
- Discuss with patients the decision to request an autopsy and suggest that patients include autopsy instruction in advanced directives.
PINELLAS PARK, Fla,-Neurologists say the autopsy that is planned to be performed on Terri Schiavo will not definitively confirm a diagnosis of persistent vegetative state.
“Persistent vegetative state or minimally conscious state is a clinical diagnosis,” says Michael De Georgia, MD, head of the neurology/neurosurgery intensive care unit at the Cleveland Clinic Foundation. “It cannot be confirmed by autopsy.”
Patients in a persistent vegetative state are a subgroup who suffer severe anoxic brain injury and progress to a state of wakefulness without awareness.
Michael Schiavo, husband and guardian of Terri Schiavo, and Mary and Bob Schindler, Ms. Schiavo’s parents, engaged in a contentious public and legal dispute over the decision to remove Ms. Schiavo’s feeding tube, but both said they wanted an autopsy and both say the post-mortem exam will provide evidence to finally nail down Ms. Schiavo’s diagnosis.
Michael Schiavo said all along that his wife was in a persistent vegetative state and that she would not want to be maintained in that state. The Schindlers contended that their daughter was minimally conscious and would not agree to have her feeding tube removed.
The tube was removed by court order on March 18 and neither the intercession of Congress nor more than a score of court challenges succeeded in replacing the tube.
“The [pathologic examination of the] brain can’t tell if there is a persistent vegetative state or not,” says Harvard neuropathologist E. Tessa Hedley Whyte, MD. “The autopsy will show damage – probably mostly scarring now – and that damage will most likely correspond to some extent to what was seen on images.”
According to court records, CT scans performed in 1996 and 2002 revealed “diffuse encephalomalacia and infarction consistent with anoxia, hydrocephalus ex vacuo, neural stimulator present.”
Dr. De Georgia says that the extent of brain damage, confirmed on autopsy, “does reflect the absence of viable brain cells and the fewer brains cells a patient has the less likely it is that the patient will be conscious. But there is no standard cutoff that says if you lose this many brain cells you are in a persistent vegetative state.”
Michael Williams, MD, an associate professor at Johns Hopkins in Baltimore, puts it this way. “If you only had the brain to look at and you didn’t know anything about the history of the patient, pathology alone cannot prove or disprove a diagnosis of persistent vegetative state.” Dr. Williams says it is likely that autopsy will show “widespread damage to the cortex – a condition called laminar necrosis – and it is likely that there will also be significant damage to the thalamus.” While Dr. Williams says the autopsy can’t confirm the diagnosis of persistent vegetative state, he says that receiving an autopsy report sometimes helps a family that is struggling to accept the diagnosis. “Sometimes additional evidence from a CT scan or an autopsy report – something concrete – helps bring some final understanding or acceptance,” he said.