Jesus said that when annoyed. He had cured a few sick people, and then various worthies were making out that He had done it through the power of Satan. It is quite impossible to get through to people as determined as that. However it probably doesn’t mean that all hope was lost, merely that they were putting up exceptionally difficult obstacles to salvation.
If a person continually and persistently resists the Holy Spirit, then there is no One who can convict the person of sin, and then He is unable to repent, because of the lack of realization of sin.
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