Authorities-misinterpreting-covid-19-trial-data-with-disastrous-results-Canadian-researchers-say

[josie_L]

Authorities misinterpreting COVID-19 trial data with 'disastrous' results, Canadian researchers say | National Post

When British scientists studying potential treatments for COVID-19 released early results on hydroxychloroquine in June, it was not good news.

For patients sick enough with the coronavirus to be hospitalized, there was no evidence the controversial malaria drug did them any good. The RECOVERY trial found the same for the HIV therapy lopinavir.

The findings had a dramatic effect. Around the world ethics boards and funding bodies ended “dozens if not hundreds” of studies on hydroxychloroquine and lopanivir, says Edward Mills, a Canadian clinical trials expert.

The problem with that, he says, is that many of those other trials were looking at the medicines as a treatment for outpatients in a milder phase of the disease, or as a “prophylaxis” to prevent infection in the first place.

The impact on severely ill patients — what the widely respected U.K. trial examined — was largely irrelevant to their work, says Mills, a McMaster University professor who advises the Gates Foundation on clinical trials.

 

[Ridgerunner]

Whether it’s a worthwhile treatment or not is now essentially irrelevant, since it’s a political issue rather than a medical one. Likely it will remain so.

 

[Zzyzx_Road]

At this point, it is probably safe to say HCQ doesn’t help after the patient has to go to the hospital because the viral load is too much at that point and other treatments must be used instead.

However, its usefulness as a prophylaxis and/or as a keep an ill patient out of the hospital treatment is not ruled out entirely. But it’s more difficult to determine that for this or any other prophylactic because so many infected persons never need to go to the hospital in the first place and that’s the standard that any outpatient treatment has to meet to find its usefulness in keeping even more patients out of hospitals.

That said, HCQ with zinc is very cheap and only so many days of treatment would be required. So what’s the utility of that? Spend a small amount of money and hope the difference it makes keeps enough additional people out of the hospital to make it worth using?

Of course that is not how Big Pharma and Big Hospital think. They want patients inside and getting treated by money maker treatments for which they can charge the government boo koo bucks.

 

[Cathoholic]

Quote from josie_L . . .

For patients sick enough with the coronavirus to be hospitalized, there was no evidence the controversial malaria drug did them any good.

Thanks for posting josie_L.

The evidence (admittedly anecdotal combined with the physiology) suggests HCQ is very effective in treating COVID-19.

It is augmented by zinc as well perhaps but that is an intracellular phenomenon.

HCQ has extra-cellular benefits AND intracellular benefits against Corona virus apparently. (In this post I will focus almost exclusively on the extracellular benefits.)

WHY they kept doing studies on LATE Corona virus patients (hospitalized and in some cases having oxygen saturation problems) is beyond me.

It should not work there (except for those patients with a cytokine storm. In which case it MAY be quite helpful).

Yet they kept designing studies meant to treat patients that you can see (physiologically ) would not benefit from HCQ. Then kept trotting these expected results out.

But (wrongly) concluding HCQ dies not help in EARLY COVID-19 too.

Equivocating (baiting and switching) their wrong cohorts and applying those predictably bad results to people they had no business applying them too. The EARLY COVID-19 patient.

This along with a couple of influential but FAKE studies in two of the most influential medical journals in the world, The Lancet (from England) and The New England Journal of Medicine (NEJM - from America) resulted in many suspended HCQ studies that were in progress and needed to be done.

The World Health Organization (WHO) suspended a HCQ study based upon these FAKE studies published by the Lancet and NEJM.

The Lancet and NEJM eventually retracted these FAKE studies after they came under public scrutiny (but WHY would this occur in the first place is anybody’s guess and neither has made an effort to publicly explain this debacle) but it was too late for many.

The WHO to its credit, quietly resumed their HCQ studies when it these FAKE “studies” were retracted, but even they have lost some credibility at this point for “biting” on the fake studies to begin with.

1/2 . . .

 

[Cathoholic]

2/2 . . . .

When you think through the physiology, it is clear WHY HCQ, must be used early.

It is also clear WHY HCQ used late would yield significantly less benefit.

The HCQ works by blocking the AVE-II receptors that the COVID-19 virus depends upon to enter into the respiratory cell.

The COVID-19 then cannot enter the cell and quietly “dies” in the airway without doing any harm (if those ACE-II receptors are blocked off to them).

The LATE COVID-19 studies critical of HCQ therapy took LATE patients and studied THEM.

OK Cathoholic. What was wrong with THAT?

Well it was wrong because much if the viral loss was ALREADY IN the cells.

So the benefit of the HCQ was lost!

It is like having an impervious barn door placed upon a chicken coops AFTER the weasel is in the hen house.

Then going into the hen House the next morning and wondering WHY un the heck “all my hens are dead!!??”

It doesn’t make sense.

Dud these guys DESIGN bad cohort studies on purpose?

Hopefully not. But if they just thought through the physiology first, it was quite predictable that they were designing studies that were bound to fail.

HCQ still needs to be properly studied in the correct cohorts.

Until then, all the evidence we have says it is a great treatment for COVID-19 as so many doctors that see patients worldwide gave already attested to.

But since HCQ us an old generic drug, nobody will get rich off of it.

Add in a political dimension and it is going to be years before HCQ ever gets an appropriate examination.

Keep up the great work josie_L and thanks for starting this informational thread!

 

[Cathoholic]

Typo alert!

Cathoholic (me) in post above . . .

The HCQ works by blocking the AVE-II receptors that the COVID-19 virus depends upon to enter into the respiratory cell.

I should have wrote . . .

The HCQ works by blocking the ACE-II receptors that the COVID-19 virus depends upon to enter into the respiratory cell.

Apologies.

“Did” instead of “Dud” and looks like a couple other minor typos too.

But the ACE-II receptor aspect is important enough to self-correct on (if you attempt to do more research, you won’t find anything if you look for “AVE-II” receptors).