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The tree of one percent
…The biggest branch is the biggest problem
For many biologists concerned with life’s deeper relationships, the longest and most strongly supported branch in many current versions of the tree of life as depicted in Figure 1a or in recent papers 9,16] is also the most misleading: the central branch that implies a sister-group relationship between eukaryotes and archaebacteria 9,13]. It is misleading because at the level of genome-wide patterns of sequence similarity, eukaryotes are far more similar to eubacteria than they are to archaebacteria 56]. Put another way, eukaryotes possess more eubacteria-related genes than they possess archaebacteria-related genes 56,57]. This has escaped the attention of almost everyone, and is one of evolutionary biology’s best-kept secrets, at least in circles where the rRNA tree is thought to speak for the whole genome.
…The biggest branch is the biggest problem
For many biologists concerned with life’s deeper relationships, the longest and most strongly supported branch in many current versions of the tree of life as depicted in Figure 1a or in recent papers 9,16] is also the most misleading: the central branch that implies a sister-group relationship between eukaryotes and archaebacteria 9,13]. It is misleading because at the level of genome-wide patterns of sequence similarity, eukaryotes are far more similar to eubacteria than they are to archaebacteria 56]. Put another way, eukaryotes possess more eubacteria-related genes than they possess archaebacteria-related genes 56,57]. This has escaped the attention of almost everyone, and is one of evolutionary biology’s best-kept secrets, at least in circles where the rRNA tree is thought to speak for the whole genome.