Hey THurifer2
Sigh I forget science education is somewhat lacking in this world.
First Humans are Animals and Mammals we evolved or were “created” with a very similiar plan to the rest of the mammals including rats. When we test for drugs, for anything, one of the steps is Rats because they have similiar systems to us. We can not test toxicity effects directly on Humans because of silly human rights. I know, its sad (sarc) The Nazis did it though.
Second In the world of science we dont like definitives, its not a religion were God comes down and gives you a direct answer in a pretty bow. In science you have to think and figure things out and question question question. We dont trust the answer from God we have to use evidence. Also one experiment does not prove anything because there are a lot of factors at work here. So most people say support or even maybe.
Third I only quickly grabbed one reference you want some more references here you go
(Glycophosphate = Atrazine)
Title: Atrazine-induced aromatase expression is SF-1 dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans
Author(s): Fan WQ (Fan, WuQiang), Yanase T (Yanase, Toshihiko), Morinaga H (Morinaga, Hidetaka), Ondo S (Ondo, Shigeki), Okabe T (Okabe, Taijiro), Nomura M (Nomura, Masatoshi), Komatsu T (Komatsu, Tomoko), Morohashi KI (Morohashi, Ken-Ichirou), Hayes TB (Hayes, Tyrone B.), Takayanagi R (Takayanagi, Ryoichi), Nawata H (Nawata, Hajime)
Source: ENVIRONMENTAL HEALTH PERSPECTIVES 115 (5): 720-727 MAY 2007
Document Type: Article
Language: English
Cited References: 92 Times Cited: 0
Abstract: BACKGROUND: Atrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation of cAMP.
METHODS: We compared steroidogenic factor 1 (ST-1) expression in atrazine responsive and non-responsive cell lines and transfected SF-1 into non-responsive cell lines to assess SF-1’s role in atrazine-induced aromatase. We used a luciferase reporter driven by the SF-1-dependent aromatase promoter (ArPlI) to examine activation of this promoter by atrazine and the related simazine. We mutated the SF-1 binding site to confirm the role of SF-1. We also examined effects of 55 other chemicals. Finally, we examined the ability of atrazine and simazine to bind to SF-1 and enhance SF-1 binding to ArPII.
RESULTS: Atrazine-responsive adrenal carcinoma cells (H295R) expressed 54 times more SF-1 than nonresponsive ovarian granulosa KGN cells. Exogenous SF-I conveyed atrazine-responsiveness to otherwise nonresponsive KGN and NIH/3T3 cells. Atrazine induced binding of SF-I to chromatin and mutation of the SF-1 binding site in ArPll eliminated SF-1 binding and atrazine-responsiveness in H295R cells. Out of 55 chemicals examined, only atrazine, simazine, and benzopyrene induced luciferase via ArPll. Atrazine bound directly to SF-1, showing that atrazine is a ligand for this ‘’ orphan ‘’ receptor.
CONCLUSION: The current findings are consistent with atrazine’s endocrine-disrupting effects in fish, amphibians, and reptiles; the induction of mammary and prostate cancer in laboratory rodents; and correlations between atrazine and similar reproductive cancers in humans. This study highlights the importance of atrazine a, a risk factor in endocrine disruption in wildlife and reproductive cancers in laboratory rodents and humans.
Endocrine is the system that has to do with hormones incase you dont know
Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption
Author(s): Thomas P (Thomas, Peter), Dong J (Dong, Jing)
Source: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 102 (1-5): 175-179 Sp. Iss. SI, DEC 2006
Title: Experimental parameters affecting sensitivity and specificity of a yeast assay for estrogenic compounds: results of an interlaboratory validation exercise
ANALYTICAL AND BIOANALYTICAL CHEMISTRY 386 (5): 1419-1428 NOV 2006
Estrogenicity of pyrethroid insecticide metabolites
JOURNAL OF ENVIRONMENTAL MONITORING 8 (1): 197-202 JAN 2006
Evaluation of estrogenic activities of pesticides using an in vitro reporter gene assay
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH 15 (4): 271-280 AUG 2005
Estrogenicity of pyrethroid insecticide metabolites
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 68 (23-24): 2175-2186 DEC 10 2005
If you want more just do a little research go to a journal search engine and put in you search factors. You will get more. A Lot more.