I have only been on I-80/I-90, and it is ok. (Moved from the upper midwest to NY and back again). But you will have lots of tolls on I-80. Chicago, Indiana, Ohio. Getting one of the I-Pass/Zooms are probably worth it. But make sure you check construction maps. Because that will probably determine which route worse. (When we moved back last summer the construction on I-80 was pretty terrible, we thought we were going to see orange forever). Also depending on where you are getting on/off on I-80 you will have to navigate either around or through Chicago, which can be a bear (avoid rush hour and lunch). But you won’t have to go through Cleveland and their ridiculous 90 degree turns. (Which is after 80 and 90 split.