There were Greek Orthodox in Italy who were targeted by the Inquisition. For example, we read:
“The Spanish Inquisition was set up by King Ferdinand of Aragon and Queen Isabella of Castile in 1478 with the **forced **approval of Pope Sixtus IV. In contrast to the previous Inquisition,
it operated completely under royal authority, though staffed by secular clergy and orders, and independently of the Holy See. It aimed primarily at converts from Judaism and Islam (who were still residing in Spain after the end of the Moor control of Spain), who were suspected of either continuing to adhere to their old religion (often after having been converted under duress) or having fallen back into it, and later at Protestants; in Sicily and Southern Italy, which were under Spanish rule, it targeted Greek Orthodox Christians. After religious disputes waned in the 17th century, the Spanish Inquisition more and more developed into a secret police against internal threats to the state.”
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