Actually, what first came to mind for me was a scene from A Beautiful Mind (2001). It’s far from graphic, but the wife of the main character reaches over and begins touching her husband. He refuses her and rolls over. She asks, “Is it the medication?” (He’s on psychiatric medication because of persistent hallucinations.) She then gets up and goes into the bathroom, throws and breaks a glass, and screams.
It’s not a sexy scene. The characters are clothed the whole time, and it’s meant to demonstrate just how frustrating and agonizing this situation has become. This scene also serves as the breaking point for the protagonist - he quits taking the medication, because he can’t stand how it hurts his wife.
Is the scene intimate? Yes, but not pornographic.