Actually, the ToE is not based on observations.
You are grossly misinformed here. Mutations, natural selection, neutral drift, founder effect, sexual selection and the other mechanisms of evolution have all been observed. How do you think that a multiply resistant bacterium like MRSA appeared?
We do not observe molecules randomly coming together to create life.
That is not evolution, but Abiogenesis. Darwin’s book is “On the Origin of Species”, not “On the Origin of Life and Species”. There is currently not yet a theory of Abiogenesis. All we have are a number of possible hypotheses, which are being examined to see which one stand up. Science works by putting up hypotheses and knocking them down. Last one standing gets to be a theory, until it is replaced by a better theory.
All known alterations in DNA, not caused by the inherent properties of cells, such as horizontal gene transfer or translocations, that are built in mechanisms for adaptation and to promote diversity in organisms and their environments, are at best neutral, or at least offset by having two chromosomes.
So many errors. Bacteria do not have chromosomes. Chromosomes are only found in Eukaryotes, and I am not certain that all Eukaryotes have them. It is possible that a single-celled asexually reproducing eukaryote will not.
Most mutations are neutral. Most of the rest are deleterious, but beneficial mutations do exist. HbC and Apo-AI Milano are two examples of beneficial mutations in humans. Roundup resistance is an example in plants.
Theyy ultimately result in disease, and that is why your beloved XXX crayfish will survive only about 100,000 years, because of the accumulation of chromosomal damage, caused by random physical events on the genome. It will be disappear due to “natural selection”.
All species go extinct in time. Extinction is not a disproof of evolution. Your argument here is completely irrelevant.
I do understand the philosophical basis for evolution but believe it to be relevant only in the world of Marvel Comic Books.
Evolution is science, not philosophy. That may be why you have such a strange attitude to it; you have it wrongly categorised. You would not expect a mention of God in a textbook on gravity, nor should you expect and mention of God in a textbook on biology.
The most you are likely to get is Darwin:
There is grandeur in this view of life, with its several powers, having been originally breathed by the Creator into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved.
Darwin, Origin (6th edition)