His third concern is the most fundamental, and arguably underpins the other two. Our experience, in all its manifold variety, appears to be invisible to science: ‘Our mental experience is not open to observation through any sense organ … . The perceptible [is] rooted in sense. Our mental experience has no such channel of entrance to the mind. It is already of the mind ….’
Thus despite his conviction that energy and mind must be two ‘contrasted constituents’ of a unity, that both thought and action are ‘psycho-physical throughout,’ Sherrington could not yet see a way across the gap dividing mind and matter. The brain, he firmly, believed is the indispensable organ of experience, the ‘provider of mind’—yet however we gaze at its workings we find not experience, but only neurons, in their cosmic numbers, interlinked and ceaselessly communicating; we can discern nothing that corresponds to a subject of experience, who finds meanings in the world; and, worst of all, there seems to be no possibility of bringing the object of interest, experience, properly within the scientist's field of observation. Thus ‘To man's understanding the world remain[s] obstinately double.’ Sherrington felt that a biologist should ask how ‘brain and mind go together’—but also ‘… make plain how far he is from answer.’"