Fauci has made important scientific observations that contributed to the understanding of regulation of the human immune response, and is recognized for delineating the mechanisms whereby
immunosuppressive agents adapt to that response. He developed therapies for formerly fatal diseases such as
polyarteritis nodosa,
granulomatosis with polyangiitis, and
lymphomatoid granulomatosis. In a 1985
Stanford University Arthritis Center Survey of the American Rheumatism Association, membership ranked Fauci’s work on the treatment of polyarteritis nodosa and granulomatosis with polyangiitis as one of the most important advances in patient management in
rheumatology over the previous 20 years.
[16][17]
Fauci has contributed to the understanding of how
HIV destroys the body’s defenses leading to the progression to
AIDS. He has outlined the mechanisms of induction of HIV expression by endogenous
cytokines.
[17] Fauci has worked to develop strategies for the therapy and immune reconstitution of patients with the disease, as well as for a
vaccine to prevent HIV infection. His current research is concentrated on identifying the nature of the immunopathogenic mechanisms of HIV infection and the scope of the body’s immune responses to HIV.