Good question. From everything i’ve read Alexander the Great was a Greek pagan who had no contact with any Jewish people or the Torah prior to his siege of Tyre. This is no credible historian of ancient history that teaches Alexander the Great knew prior to sacking the island city of Tyre the writings of Ezekiel.
There is an interesting fable in the Jewish Midrash, which is also echoed in the writings of the ancient Jewish historian Josephus, that Alexander the Great met with the Jewish religious leaders of Jerusalem. However, both the Midrash and Josephus indicate that this occurred after Alexander conquered Tyre and the rest of ancient Palestine.
The online Jewish encyclopedia accurately points out that modern historians consider these stories fables that were likely written two hundred years after Alexander’s death in Alexandria in Egypt. To read more, see this link:
jewishencyclopedia.com/view.jsp?artid=1120&letter=A
It’s interesting to me that Alexander’s tutor as a boy was Aristotle, who was a student of Plato the student of Socrates. Some say that Socrates, more than any other ancient Greek thinker, was open to the idea that there is one God above all pagan gods who is the source of all wisdom. This suggests why Alexander might be tolerant to the Jewish people who believed their God to be the God of all Gods and the source of all wisdom and would spare Jerusalem. However, there is no historical basis for this.