A new website is on the Internet called The Third Way. This is a list of mainstream scientists (not Intelligent Design, Creationists, etc.) who are saying Darwin is falsified. When I first looked at it, there were 17 scientists listed. Now there are 29, and several are very prominent biologists, including Scott Gilbert, Denis Noble, and Eugene Koonin. (Unfortunately, they also say that Creationism has been falsified by science, which is interesting since we are told that they are different realms, but I’ll leave that for another day.)
If you go to “People” on the website, you will see Dr. Eugene Koonin is a Senior Investigator and the leader of the Evolutionary Genomics Group in the Computational Biology Branch of the National Center for Biotechnology Information. He received his Ph.D. in 1983 from Department of Biology, Moscow State University in Molecular Biology. He is the author of The Logic of Chance: The Nature and Origin of Biological Evolution (2011) and has authored and co-authored over 600 papers.
thethirdwayofevolution.com/people/view/eugene-koonin
Koonin has been on the forefront of comparative genomics at the National Center of Biotechnology Information, a division of NIH. NIH has been the leader of the Human Genome and ENCODE Projects.
Koonin’s Quote:
"The summary of the state of affairs on the 150th anniversary of the Origin is somewhat shocking: in the post-genomic era, all major tenets of the Modern Synthesis are, if not outright overturned, replaced by a new and incomparably more complex vision of the key aspects of evolution. So, not to mince words, the Modern Synthesis is gone. "
(The Origin at 150: is a new evolutionary synthesis in sight? Trends Genet. Nov 2009; 25(11): 473–475)
Do we know how long a billion years is?
When we figure possible number of combinations for DNA needed for a free-living organism, we use the total number of necessary DNA bases as the exponent, one million (see the reference after this paragraph). The number of possible types of DNA bases, the 4 found in living things, is the mathematical base. Therefore the total number of possible combinations is 4^1,000,000. This can be converted to the more familiar base 10 which rounds off to 10^600,000 (these numbers are approximate but close enough to be useful for the concepts).
ncbi.nlm.nih.gov/pubmed/18948295
Genomics of bacteria and Archaea: the emerging dynamic view of the prokaryotic world.
The fastest chemical reactions are usually no faster than a picosecond, which means 10^15 reactions per second. All the possible sets of one million (10^6) bases on Earth is 4.4 x 10^48 (available bases) divided by 10^6 = 4.4 x 10^42. Multiply that times the rate of chemical reactions per second (10^15) times the seconds in 500,000 years (1.58 x 10^16), you get, rounded off, 7 x 10^73. This would be a limit to the number of “tries” for all the chemical reactions on Earth in 500 million years to mix bases together in hopes they would come up with a set of one million DNA bases in a specific order.
A “try” is similar to trying to guess numbers between a certain range. If you are asked to guess a number between 1 and 10, you are much more likely to “hit” the right number than if the range was between 1 and 1,000,000. If for some reason you had to keep guessing until you got it right, you would probably be done a lot sooner for the 1 to 10 set.
We started with talking about needing about 1 million base pairs of DNA for a free-living organism. For just one short protein around 100 amino acids long, the DNA would have to be about 300 bases long for just that protein (3 bases of DNA to code for one amino acid of protein.) Even if there
were nothing to interfere with random combinations of the correct bases, it would take on average around 4^300 or about 4 x 10^180 tries to get one specific DNA sequence for one protein. Using figures above, the Earth would allow no more than 10^78 tries (1.5 x 10^46 bases) x (1.58 x 10^16 seconds) x (10^15 chemical reactions per second)] for combinations of 300-base DNA sequences.
To compare these numbers with a few other physical phenomena, the estimated number of particles in the universe is about 10^90. The maximum number of actions possible in a second is 10^49 (some talk about quantum physics allowing for more, but we and DNA exist in Newtonian space). The number of seconds in a 14 billion year old universe is no more than 10^20.
The maximum number of organisms on Earth calculated in relation to water volume is 10^50 in 4 billion years.
womanatwell.blogspot.com/p/creation-biology.html