I get that the whole idea of the show is shock value, and that they make fun of everyone, but is nothing sacred!? Apparently not.
Around here, everyone watches South Park, and almost religiously exhalt it. Sad sad thing is, even though about 90% of the group is Catholic they won't find a single thing wrong with it.
Really this is a case of darned if we do, darned if we don't. If we make a fuss, it will only encourage them to attack more, and more offensive. If we don't do a thing, no dout it will be supported with thunderous applause by the army of lapsed Catholics, having the same effect as if we had maded a fuss. Choosing not to watch is a good idea, but really I don't think orthoxed christians is a large part of their target audiance, so, in the end nothing happens.
The only thing we can do, is pray for everyone one involved in the show and perhaps the audiance who will probably laugh their behinds off. I may be no judge of souls, but surely insulting the Blessed Virgin is no path to heaven.