I’m pretty sure mRNA never actually leaves cells and even if it could, it cannot replicate by itself.
That’s good to know. That’s kind of what I figured. I wasn’t so concerned about the mRNA replicating outside of the cell. I was more pondering a scenario in which the mRNA is released from a cell (e.g. when the cell dies), can it find its way into another cell?
My suspicion was that, “No it couldn’t,” because from what I had read, the developers of the mRNA vaccines had to develop a sophisticated lipid nanomolecule to allow it to pass through the cell membrane, and without that nanomolecule, it couldn’t make it into new cells, but I didn’t know for sure.
The mRNA goes into the cell that had the area of the old one it occupied. It isn’t replicated during mitosis.
Also good to know. Thanks.
I didn’t really think it was replicated during the standard process of mitosis. But we do know that the
cell is replicating the mRNA, in the case of the
in vivo self-replicating mRNA vaccines described in the article I cited above.
Since the cell therefore likely has multiple copies of this mRNA inside it when it undergoes mitosis, how would it be determined which of the two copies of the cell gets the mRNA? That’s mainly what I was wondering.
The reason I was pondering that is because a U.S.-based healthcare company named Vizient had a
comparison chart on their site describing the pros and cons of different vaccine technologies. And among the potential disadvantages of the mRNA vaccines, they listed “Biodistribution and persistence of the induced antigen expression,” which seems to imply the cells with the antigen (the coronavirus spike protein) somehow spread throughout the body, or continue to produce this antigen beyond the expected or desired time frame targeted by the vaccine.
And if they were concerned about that possibility, it made me wonder what type of scenario or mechanism would produce that kind of outcome. If the mRNA can’t travel from cell to cell, I thought maybe mitosis could produce the “biodistribution and persistence” they were worried about, but I’m not really sure.