Although there was no adequate control group and the study was conducted at a single center, this is the first study to use PEP with HCQ as an outbreak response strategy against COVID-19 in an LTCH. A total of 92 hospital staff, including physicians and nurses, showed negative PCR results after 14 days of quarantine even though they did not receive PEP. From these results, we could not conclude that PEP is effective for prevention of COVID-19 in close contacts. However, there were differences in the level of risk exposure: patients and careworkers might have had close contact with the index case (high-risk exposure) and most hospital staff were at low-risk exposure. Nonetheless, this study showed that all 189 patients and 22 careworkers who received PEP did not develop COVID-19.
5. Conclusion
In this study, PEP with HCQ was implemented safely under proper monitoring and no additional patients were diagnosed with COVID-19. Randomized clinical studies are needed to evaluate whether PEP is an effective option for an outbreak response strategy against COVID-19 in LTCHs.