umamibella . . .
The length of immunity offered by a vaccine is yet to be determined. That means no one has any idea at this point how long vaccine protection will last. You cannot know different yourself.
True. Nobody knows for sure.
But if you take into consideration vaccines and physiologically how they work, a safe effective vaccine for a primarily respiratory-transmitted disease (like Corona virus is) is almost going to be impossible.
At least with current technology.
That’s WHY we can’t get a good “cold” vaccine.
That’s WHY you need frequent re-vaccinations (and even then, they often do not work) with influenza.
Just think about the already well-known physiologic mechanism.
The virus is going to gain entrance into your respiratory epithelium via attachment to ACE II receptors.
The way it got there in the first place was
via the airway.
The reason it got to the airway in the first place was you inhaled it (or touched your infected hand or whatever to a facial mucosal surface (nose, eye, mouth) and the virus “slinkyed” down your airway.
The vaccines we have now (IgG mediated) are going to stimulate antibody in the
bloodstream.
Since the virus particles bypass the bloodstream and directly infect your respiratory epithelium via your airway (NOT via your bloodstream),
they can enter your respiratory epithelium unimpeded. Even with IgG antibody (blood antibody) already present!
There (theoretically) is a WAY we could attack the virus in the airway with antibody.
But that would call for IgA antibody (and we know almost nothing as to how to manipulate this class of antibodies compared to the usual IgG antibody).
This reason, physiologically speaking, is almost CERTAINLY WHY, Dr. Fauci has said
any Corona virus vaccine we have will likely have little effectiveness.
Dr. Anthony Fauci says chance of coronavirus vaccine being highly effective is ‘not great’ World News
Dr. Anthony Fauci says chance of coronavirus vaccine being highly effective is ‘not great’ Published Fri, Aug 7 20201:57 PM EDTUpdated Fri, Aug 7 20205:04 PM EDT
Berkeley Lovelace Jr.@BerkeleyJr Noah Higgins-Dunn@higginsdunn Key Points White House coronavirus advisor Dr. Anthony Fauci that the chances of scientists creating a highly effective vaccine — one that provides 98% or more guaranteed protection — for the virus are slim. Scientists are hoping for a coronavirus vaccine that is at le…
That being said, studies SHOULD go forth here as IgG antibody, SHOULD help minimize complications as the virus will go from the respiratory epithelium to the heart (or liver, or brain, or wherever) via the bloodstream.
So SOME infectious complications MAY be MINIMIZED.
I am all for a good, safe, ethical, reliable vaccine against Corona virus.
Many have only a very rudimentary understanding of just how daunting this task will be though.